NFATC2IP

In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 Arg-3-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).
Full Name
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
Function
In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity).

Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).
Biological Process
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Cytoplasm
Note: TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus.
PTM
Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production.
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Anti-NFATC2IP antibodies

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Mouse Anti-NFATC2IP Recombinant Antibody (2D7-A10) (CBMAB-A5923-LY)

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Target: NFATC2IP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2D7-A10
Application*: WB, E
Datasheet SDS

Mouse Anti-NFATC2IP Recombinant Antibody (B-1) (CBMAB-N2167-WJ)

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Target: NFATC2IP
Host: Mouse
Specificity: Human
Clone: B-1
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-NFATC2IP Recombinant Antibody (CBWJN-0367) (CBMAB-N2166-WJ)

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Target: NFATC2IP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJN-0367
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-NFATC2IP Recombinant Antibody (CBWJN-0336) (CBMAB-N2165-WJ)

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Target: NFATC2IP
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBWJN-0336
Application*: E, IF, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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