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NFATC2IP

In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 Arg-3-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).

Full Name

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein

Function

In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity).

Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).

Biological Process

Positive regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus
Cytoplasm
Note: TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus.

PTM

Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production.

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Anti-NFATC2IP antibodies

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Mouse Anti-NFATC2IP Recombinant Antibody (2D7-A10) (CBMAB-A5923-LY)

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Target: NFATC2IP

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2D7-A10

Application*: WB, E

Mouse Anti-NFATC2IP Recombinant Antibody (2D7-A10)

Mouse Anti-NFATC2IP Recombinant Antibody (B-1) (CBMAB-N2167-WJ)

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Target: NFATC2IP

Host: Mouse

Specificity: Human

Clone: B-1

Application*: WB, IP, IF, E

Mouse Anti-NFATC2IP Recombinant Antibody (B-1)

Mouse Anti-NFATC2IP Recombinant Antibody (CBWJN-0367) (CBMAB-N2166-WJ)

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Target: NFATC2IP

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBWJN-0367

Application*: E, IP, WB

Mouse Anti-NFATC2IP Recombinant Antibody (CBWJN-0367)

Mouse Anti-NFATC2IP Recombinant Antibody (CBWJN-0336) (CBMAB-N2165-WJ)

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Target: NFATC2IP

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBWJN-0336

Application*: E, IF, WB

Mouse Anti-NFATC2IP Recombinant Antibody (CBWJN-0336)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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