Mouse Anti-NFATC2IP Recombinant Antibody (CBWJN-0336) (CBMAB-N2165-WJ)

Name: Mouse Anti-NFATC2IP Recombinant Antibody (CBWJN-0336)
SKU: CBMAB-N2165-WJ
Rating: 5 (1 reviews)

See all NFATC2IP antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBWJN-0336

Application

ELISA, IF, WB

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.2

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein

Introduction

In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 Arg-3-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity). Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).

Entrez Gene ID

84901

UniProt ID

Q8NCF5

Alternative Names

Nuclear Factor Of Activated T Cells 2 Interacting Protein; Nuclear Factor Of Activated T-Cells, Cytoplasmic, Calcineurin-Dependent 2 Interacting Protein; Nuclear Factor Of Activated T-Cells, Cytoplasmic 2-Interacting Protein; Nuclear Factor Of Activated T-Cells 2 Interacting Protein; 45 KDa NF-AT-Interacting Protein; 45 KDa NFAT-Interacting Protein;

Function

In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity).

Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).

Biological Process

Positive regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus
Cytoplasm
Note: TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus.

PTM

Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production.

Cho, T., Zhao, Y., Olivieri, M., Hoeg, L., Setiaputra, D., & Durocher, D. (2023). Chemogenetic profiling of ubiquitin-like modifier pathways identifies NFATC2IP as a mediator of SUMO-dependent genome integrity. bioRxiv, 2023-06.

LI, X., SHAO, X., KOU, M., XUE, Q., BRAY, G., SACKS, F., & QI, L. (2023). 1229-P: DNA Methylation near NFATC2IP and Changes in Clinical Cardiovascular Health—The POUNDs Lost Trial. Diabetes, 72(Supplement_1).

Huang, T., Gu, W., Liu, E., Wang, B., Wang, G., Dong, F., ... & Xu, G. (2022). miR-301b-5p and its target gene nfatc2ip regulate inflammatory responses in the liver of rainbow trout (Oncorhynchus mykiss) under high temperature stress. Ecotoxicology and Environmental Safety, 242, 113915.

Xu, X., Li, N., Wang, Y., Yu, J., & Mi, J. (2021). Calcium channel TRPV6 promotes breast cancer metastasis by NFATC2IP. Cancer Letters, 519, 150-160.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-NFATC2IP Recombinant Antibody (CBWJN-0336)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-NFATC2IP Recombinant Antibody (2D7-A10) (CAT#: CBMAB-A5923-LY)

Mouse Anti-NFATC2IP Recombinant Antibody (B-1) (CAT#: CBMAB-N2167-WJ)

Mouse Anti-NFATC2IP Recombinant Antibody (CBWJN-0367) (CAT#: CBMAB-N2166-WJ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry