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Mouse Anti-NFATC2IP Recombinant Antibody (2D7-A10) (CBMAB-A5923-LY)

The product is antibody recognizes NFATC2IP. The antibody 2D7-A10 immunoassay techniques such as: WB, ELISA.
See all NFATC2IP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2D7-A10
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
NFATC2IP (AAH18311, 1 a.a. ~ 138 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein
Entrez Gene ID
84901
UniProt ID
Q8NCF5
Alternative Names
FLJ14639; MGC126790; MGC138387
Function
In T-helper 2 (Th2) cells, regulates the magnitude of NFAT-driven transcription of a specific subset of cytokine genes, including IL3, IL4, IL5 and IL13, but not IL2. Recruits PRMT1 to the IL4 promoter; this leads to enhancement of histone H4 'Arg-3'-methylation and facilitates subsequent histone acetylation at the IL4 locus, thus promotes robust cytokine expression (By similarity).

Down-regulates formation of poly-SUMO chains by UBE2I/UBC9 (By similarity).
Biological Process
Positive regulation of transcription by RNA polymerase II Source: GO_Central
Cellular Location
Nucleus
Cytoplasm
Note: TRAF1 is associated with a fraction of NFATC2IP in the cytoplasm and prevents its translocation to the nucleus.
PTM
Methylation at the N-terminus by PRMT1 modulates interaction with the NFAT complex and results in augmented cytokine production.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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