NPEPPS

This gene encodes the puromycin-sensitive aminopeptidase, a zinc metallopeptidase which hydrolyzes amino acids from the N-terminus of its substrate. The protein has been localized to both the cytoplasm and to cellular membranes. This enzyme degrades enkaphalins in the brain, and studies in mouse suggest that it is involved in proteolytic events regulating the cell cycle.

Full Name

AMINOPEPTIDASE PUROMYCIN SENSITIVE

Function

Aminopeptidase with broad substrate specificity for several peptides. Involved in proteolytic events essential for cell growth and viability. May act as regulator of neuropeptide activity. Plays a role in the antigen-processing pathway for MHC class I molecules. Involved in the N-terminal trimming of cytotoxic T-cell epitope precursors. Digests the poly-Q peptides found in many cellular proteins. Digests tau from normal brain more efficiently than tau from Alzheimer disease brain.

Biological Process

Cellular response to hypoxiaManual Assertion Based On ExperimentIDA:UniProtKB
Peptide catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of protein targeting to mitochondrionManual Assertion Based On ExperimentHMP:ParkinsonsUK-UCL
Protein polyubiquitinationTAS:Reactome
ProteolysisManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm, cytosol
Nucleus