NPFFR1

Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Full Name

Neuropeptide FF Receptor 1

Function

Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.

Biological Process

G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-43
Helical: 44-64
Cytoplasmic: 65-80
Helical: 81-101
Extracellular: 102-117
Helical: 118-138
Cytoplasmic: 139-158
Helical: 159-179
Extracellular: 180-214
Helical: 215-235
Cytoplasmic: 236-271
Helical: 272-292
Extracellular: 293-307
Helical: 308-328
Cytoplasmic: 329-430