NPNT

Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity).

Full Name

Nephronectin

Function

Biological Process

Branching involved in ureteric bud morphogenesisBy SimilarityISS:BHF-UCL
Cell-cell adhesion mediated by integrinBy SimilarityISS:BHF-UCL
Cell-matrix adhesionBy SimilarityISS:BHF-UCL
Cellular response to tumor necrosis factorBy SimilarityISS:BHF-UCL
Establishment of protein localizationIEA:Ensembl
Extracellular matrix organizationBy SimilarityISS:BHF-UCL
Pilomotor reflexIEA:Ensembl
Positive regulation of alkaline phosphatase activityIEA:Ensembl
Positive regulation of cell-substrate adhesionBy SimilarityISS:BHF-UCL
Positive regulation of ERK1 and ERK2 cascadeBy SimilarityISS:BHF-UCL
Positive regulation of osteoblast differentiationBy SimilarityISS:BHF-UCL
Positive regulation of smooth muscle contractionIEA:Ensembl
Positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiationIEA:Ensembl
Positive regulation of transforming growth factor beta receptor signaling pathwayIEA:Ensembl
Ureteric bud developmentBy SimilarityISS:BHF-UCL

Cellular Location

Secreted, extracellular space, extracellular matrix
Trapped on the cell surface or in the extracellular matrix.