NPNT

Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity).

Nephronectin

Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity).

Branching involved in ureteric bud morphogenesisBy SimilarityISS:BHF-UCL
Cell-cell adhesion mediated by integrinBy SimilarityISS:BHF-UCL
Cell-matrix adhesionBy SimilarityISS:BHF-UCL
Cellular response to tumor necrosis factorBy SimilarityISS:BHF-UCL
Establishment of protein localizationIEA:Ensembl
Extracellular matrix organizationBy SimilarityISS:BHF-UCL
Pilomotor reflexIEA:Ensembl
Positive regulation of alkaline phosphatase activityIEA:Ensembl
Positive regulation of cell-substrate adhesionBy SimilarityISS:BHF-UCL
Positive regulation of ERK1 and ERK2 cascadeBy SimilarityISS:BHF-UCL
Positive regulation of osteoblast differentiationBy SimilarityISS:BHF-UCL
Positive regulation of smooth muscle contractionIEA:Ensembl
Positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiationIEA:Ensembl
Positive regulation of transforming growth factor beta receptor signaling pathwayIEA:Ensembl
Ureteric bud developmentBy SimilarityISS:BHF-UCL

Secreted, extracellular space, extracellular matrix
Trapped on the cell surface or in the extracellular matrix.