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Mouse Anti-NPNT Recombinant Antibody (CBWJN-1503) (CBMAB-N3164-WJ)

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Datasheet
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBWJN-1503
Application
WB, IHC
Specificity
Human, Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, Trehalose
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Nephronectin
Introduction
Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity).
Entrez Gene ID
Human255743
Mouse114249
UniProt ID
HumanQ6UXI9
MouseQ91V88
Alternative Names
Nephronectin; Preosteoblast EGF-Like Repeat Protein With MAM Domain; EGFL6L; POEM; Protein EGFL6-Like;
Function
Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity).
Biological Process
Branching involved in ureteric bud morphogenesisBy SimilarityISS:BHF-UCL
Cell-cell adhesion mediated by integrinBy SimilarityISS:BHF-UCL
Cell-matrix adhesionBy SimilarityISS:BHF-UCL
Cellular response to tumor necrosis factorBy SimilarityISS:BHF-UCL
Establishment of protein localizationIEA:Ensembl
Extracellular matrix organizationBy SimilarityISS:BHF-UCL
Pilomotor reflexIEA:Ensembl
Positive regulation of alkaline phosphatase activityIEA:Ensembl
Positive regulation of cell-substrate adhesionBy SimilarityISS:BHF-UCL
Positive regulation of ERK1 and ERK2 cascadeBy SimilarityISS:BHF-UCL
Positive regulation of osteoblast differentiationBy SimilarityISS:BHF-UCL
Positive regulation of smooth muscle contractionIEA:Ensembl
Positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiationIEA:Ensembl
Positive regulation of transforming growth factor beta receptor signaling pathwayIEA:Ensembl
Ureteric bud developmentBy SimilarityISS:BHF-UCL
Cellular Location
Secreted, extracellular space, extracellular matrix
Trapped on the cell surface or in the extracellular matrix.

Garis, M., Meyer, M. D., & Lwigale, P. (2024). Expression of Nephronectin in the Descemet's membrane of mouse corneas during development and adult homeostasis. Experimental Eye Research, 240, 109797.

Honda, M., Segawa, T., Ishikawa, K., Maeda, M., Saito, Y., & Kon, S. (2022). Nephronectin influences EAE development by regulating the Th17/Treg balance via reactive oxygen species. American Journal of Physiology-Cell Physiology, 322(4), C699-C711.

Sopel, N., Ohs, A., Schiffer, M., & Müller-Deile, J. (2022). A tight control of non-canonical TGF-β pathways and MicroRNAs downregulates nephronectin in podocytes. Cells, 11(1), 149.

Al‐Hamed, M. H., Altuwaijri, N., Alsahan, N., Ali, W., Abdulwahab, F., Alzahrani, F., ... & Alkuraya, F. S. (2022). A null founder variant in NPNT, encoding nephronectin, causes autosomal recessive renal agenesis. Clinical Genetics, 102(1), 61-65.

Müller-Deile, J., Sopel, N., Ohs, A., Rose, V., Gröner, M., Wrede, C., ... & Schiffer, M. (2021). Glomerular endothelial cell-derived microRNA-192 regulates nephronectin expression in idiopathic membranous glomerulonephritis. Journal of the American Society of Nephrology, 32(11), 2777-2794.

Magnussen, S. N., Toraskar, J., Hadler-Olsen, E., Steigedal, T. S., & Svineng, G. (2021). Nephronectin as a matrix effector in cancer. Cancers, 13(5), 959.

Sarfstein, R., Lapkina-Gendler, L., Nagaraj, K., Laron, Z., & Werner, H. (2020). Identification of nephronectin as a new target for IGF1 action. European Journal of Cancer, 141, 115-127.

Magnussen, S. N., Toraskar, J., Wilhelm, I., Hasko, J., Figenschau, S. L., Molnar, J., ... & Svineng, G. (2020). Nephronectin promotes breast cancer brain metastatic colonization via its integrin-binding domains. Scientific reports, 10(1), 12237.

Lee, S., Honda, M., Yamamoto, S., Kumagai-Takei, N., Yoshitome, K., Nishimura, Y., ... & Otsuki, T. (2019). Role of nephronectin in pathophysiology of silicosis. International journal of molecular sciences, 20(10), 2581.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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