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NRDC

This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene.

Full Name

Nardilysin Convertase

Function

Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.

Biological Process

Negative regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of membrane protein ectodomain proteolysisManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of endopeptidase activityManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

cell surface
cytosol
mitochondrion

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Anti-NRDC antibodies

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Mouse Anti-NRDC Recombinant Antibody (A-8) (CBMAB-N3561-WJ)

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Target: NRDC

Host: Mouse

Specificity: Human

Clone: A-8

Application*: WB, IP, IF, E

Human NRDC ELISA Kit (V2LY-0626-LY5566)

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Target: NRDC

Sensitivity: 0.016 ng/mL

Detection Range: 0.05-10 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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