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Mouse Anti-NRDC Recombinant Antibody (A-8) (CBMAB-N3561-WJ)

This product is a Mouse antibody that recognizes NRDC. The antibody A-8 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all NRDC antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
A-8
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nardilysin Convertase
Introduction
This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Entrez Gene ID
4898
UniProt ID
O43847
Alternative Names
Nardilysin Convertase; Nardilysin (N-Arginine Dibasic Convertase); N-Arginine Dibasic Convertase; NRD Convertase; EC 3.4.24.61; NRD1;
Function
Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.
Biological Process
Negative regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of membrane protein ectodomain proteolysisManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of endopeptidase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
cell surface
cytosol
mitochondrion

Oshima, S., Sinha, R., Ohno, M., Nishi, K., Eto, K., Takaori-Kondo, A., ... & Yamamoto, R. (2024). Nardilysin determines hematopoietic stem cell fitness by regulating protein synthesis. Biochemical and Biophysical Research Communications, 693, 149355.

Ohno, M., Shiomi, H., Baba, O., Yano, M., Aizawa, T., Nakano-Matsumura, Y., ... & Nishi, E. (2024). Auxiliary roles of nardilysin in the early diagnosis of acute coronary syndrome: a prospective cohort study, the Nardi-ACS study. Internal and Emergency Medicine, 1-11.

Saijo, S., Ohno, M., Iwasaki, H., Matsuda, S., Nishi, K., Hiraoka, Y., ... & Nishi, E. (2022). Nardilysin in adipocytes regulates UCP1 expression and body temperature homeostasis. Scientific Reports, 12(1), 3449.

Xu, Y., Xiong, Q., Yang, Y., Weng, N., Li, J., Liu, J., ... & Zhu, Q. (2022). Serum nardilysin as a prognostic biomarker in pancreatic ductal adenocarcinoma. Journal of Clinical Medicine, 11(11), 3101.

Fu, J., Ling, J., Li, C. F., Tsai, C. L., Yin, W., Hou, J., ... & Chiao, P. J. (2022). Nardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic Cancer. bioRxiv, 2022-07.

Yasuda, D., Hiraoka, Y., Ohno, M., Nishi, K., Iwasaki, H., Kita, T., ... & Kume, N. (2021). Deficiency of Nardilysin in the Liver Reduces Serum Cholesterol Levels. Biological and Pharmaceutical Bulletin, 44(3), 363-371.

Yoh, T., Hatano, E., Kasai, Y., Fuji, H., Nishi, K., Toriguchi, K., ... & Nishi, E. (2019). Serum nardilysin, a surrogate marker for epithelial–mesenchymal transition, predicts prognosis of intrahepatic cholangiocarcinoma after surgical resection. Clinical Cancer Research, 25(2), 619-628.

Ikuta, K., Fukuda, A., Ogawa, S., Masuo, K., Goto, N., Hiramatsu, Y., ... & Seno, H. (2019). Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice. Gut, 68(5), 882-892.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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