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Mouse Anti-NRDC Recombinant Antibody (A-8) (CBMAB-N3561-WJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
A-8
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nardilysin Convertase
Introduction
This gene encodes a zinc-dependent endopeptidase that cleaves peptide substrates at the N-terminus of arginine residues in dibasic moieties and is a member of the peptidase M16 family. This protein interacts with heparin-binding EGF-like growth factor and plays a role in cell migration and proliferation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Entrez Gene ID
4898
UniProt ID
O43847
Alternative Names
Nardilysin Convertase; Nardilysin (N-Arginine Dibasic Convertase); N-Arginine Dibasic Convertase; NRD Convertase; EC 3.4.24.61; NRD1;
Function
Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.
Biological Process
Negative regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of membrane protein ectodomain proteolysisManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of endopeptidase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
cell surface
cytosol
mitochondrion
More Infomation

Oshima, S., Sinha, R., Ohno, M., Nishi, K., Eto, K., Takaori-Kondo, A., ... & Yamamoto, R. (2024). Nardilysin determines hematopoietic stem cell fitness by regulating protein synthesis. Biochemical and Biophysical Research Communications, 693, 149355.

Ohno, M., Shiomi, H., Baba, O., Yano, M., Aizawa, T., Nakano-Matsumura, Y., ... & Nishi, E. (2024). Auxiliary roles of nardilysin in the early diagnosis of acute coronary syndrome: a prospective cohort study, the Nardi-ACS study. Internal and Emergency Medicine, 1-11.

Saijo, S., Ohno, M., Iwasaki, H., Matsuda, S., Nishi, K., Hiraoka, Y., ... & Nishi, E. (2022). Nardilysin in adipocytes regulates UCP1 expression and body temperature homeostasis. Scientific Reports, 12(1), 3449.

Xu, Y., Xiong, Q., Yang, Y., Weng, N., Li, J., Liu, J., ... & Zhu, Q. (2022). Serum nardilysin as a prognostic biomarker in pancreatic ductal adenocarcinoma. Journal of Clinical Medicine, 11(11), 3101.

Fu, J., Ling, J., Li, C. F., Tsai, C. L., Yin, W., Hou, J., ... & Chiao, P. J. (2022). Nardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic Cancer. bioRxiv, 2022-07.

Yasuda, D., Hiraoka, Y., Ohno, M., Nishi, K., Iwasaki, H., Kita, T., ... & Kume, N. (2021). Deficiency of Nardilysin in the Liver Reduces Serum Cholesterol Levels. Biological and Pharmaceutical Bulletin, 44(3), 363-371.

Yoh, T., Hatano, E., Kasai, Y., Fuji, H., Nishi, K., Toriguchi, K., ... & Nishi, E. (2019). Serum nardilysin, a surrogate marker for epithelial–mesenchymal transition, predicts prognosis of intrahepatic cholangiocarcinoma after surgical resection. Clinical Cancer Research, 25(2), 619-628.

Ikuta, K., Fukuda, A., Ogawa, S., Masuo, K., Goto, N., Hiramatsu, Y., ... & Seno, H. (2019). Nardilysin inhibits pancreatitis and suppresses pancreatic ductal adenocarcinoma initiation in mice. Gut, 68(5), 882-892.

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For research use only. Not intended for any clinical use.

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