NRXN1

Neurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Two neurexin genes are among the largest known in human (NRXN1 and NRXN3). By using alternate promoters, splice sites and exons, predictions of hundreds or even thousands of distinct mRNAs have been made. Most transcripts use the upstream promoter and encode alpha-neurexin isoforms; fewer transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. Alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and they interact with neurexophilins. Beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. The RefSeq] Project has decided to create only a few representative transcript variants of the multitude that are possible. [provided by RefSeq]

neurexin 1

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity).

Adult behaviorManual Assertion Based On ExperimentIMP:BHF-UCL
AngiogenesisISS:UniProtKB
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion moleculesISS:BHF-UCL
Cell-cell adhesion involved in synapse maturationIC:ComplexPortal
Cellular response to calcium ionISS:ARUK-UCL
Cerebellar granule cell differentiationISS:BHF-UCL
Establishment of protein localizationISS:BHF-UCL
Gamma-aminobutyric acid receptor clusteringISS:BHF-UCL
Gephyrin clustering involved in postsynaptic density assemblyISS:BHF-UCL
Guanylate kinase-associated protein clusteringISS:BHF-UCL
Heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesISS:BHF-UCL
LearningManual Assertion Based On ExperimentIMP:BHF-UCL
Maintenance of synapse structureIC:ComplexPortal
Negative regulation of filopodium assemblyISS:BHF-UCL
Negative regulation of gene expressionManual Assertion Based On ExperimentIDA:ARUK-UCL
Neuroligin clustering involved in postsynaptic membrane assemblyISS:BHF-UCL
Neuron cell-cell adhesionISS:BHF-UCL
Neuron projection developmentManual Assertion Based On ExperimentIGI:ARUK-UCL
Neuron projection morphogenesisIC:ComplexPortal
Neuronal signal transductionManual Assertion Based On ExperimentTAS:BHF-UCL
NMDA glutamate receptor clusteringISS:BHF-UCL
Positive regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of excitatory postsynaptic potentialISS:BHF-UCL
Positive regulation of fibroblast growth factor receptor signaling pathwayManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of neuromuscular synaptic transmissionIC:ComplexPortal
Positive regulation of neuron projection developmentIC:ComplexPortal
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of presynaptic active zone assemblyManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of protein kinase A signalingManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of protein kinase B signalingManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of protein kinase C activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of protein localization to plasma membraneISS:BHF-UCL
Positive regulation of synapse assemblyManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of synaptic transmission, GABAergicIC:ComplexPortal
Positive regulation of synaptic transmission, glutamatergicISS:BHF-UCL
Postsynaptic density protein 95 clusteringISS:BHF-UCL
Postsynaptic membrane assemblyISS:BHF-UCL
Presynaptic membrane assemblyISS:BHF-UCL
Protein localization to synapseISS:BHF-UCL
Protein-containing complex assembly involved in synapse maturationISS:BHF-UCL
Receptor localization to synapseISS:BHF-UCL
Regulation of AMPA receptor activityISS:BHF-UCL
Regulation of NMDA receptor activityISS:BHF-UCL
Signal transductionISS:BHF-UCL
Social behaviorManual Assertion Based On ExperimentIMP:BHF-UCL
Synapse assemblyISS:BHF-UCL
Synapse maturationIC:ComplexPortal
Synaptic vesicle clusteringISS:BHF-UCL
Vocalization behaviorManual Assertion Based On ExperimentIMP:BHF-UCL

Cell junction, synapse, presynaptic cell membrane

Extracellular: 51-396
Helical: 397-417
Cytoplasmic: 418-472

Highly O-glycosylated and minor N-glycosylated.