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Mouse Anti-NRXN1 Recombinant Antibody (CBWJN-0273) (CBMAB-N3638-WJ)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
CBWJN-0273
Application
WB
Specificity
Mouse, Dog, Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
0.25 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
neurexin 1
Introduction
This gene encodes a single-pass type I membrane protein that belongs to the neurexin family. Neurexins are cell-surface receptors that bind neuroligins to form Ca(2+)-dependent neurexin/neuroligin complexes at synapses in the central nervous system. This complex is required for efficient neurotransmission and is involved in the formation of synaptic contacts. Three members of this gene family have been studied in detail and are estimated to generate over 3,000 variants through the use of two alternative promoters (alpha and beta) and extensive alternative splicing in each family member. Recently, a third promoter (gamma) was identified for this gene in the 3' region. Mutations in this gene are associated with Pitt-Hopkins-like syndrome-2 and may contribute to susceptibility to schizophrenia. [provided by RefSeq, Aug 2016]
Entrez Gene ID
Human9378
Mouse18189
Rat60391
Dog474589
UniProt ID
HumanQ9ULB1
MouseQ9CS84
RatQ63372
DogJ9P8D5
Alternative Names
Neurexin 1; Neurexin I-Alpha; Neurexin-1-Alpha; Neurexin I-Beta; Neurexin I; Neurexin-1;
Function
Neuronal cell surface protein that may be involved in cell recognition and cell adhesion by forming intracellular junctions through binding to neuroligins. May play a role in formation or maintenance of synaptic junctions. May mediate intracellular signaling. May play a role in angiogenesis (By similarity).
Biological Process
Adult behaviorManual Assertion Based On ExperimentIMP:BHF-UCL
AngiogenesisISS:UniProtKB
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion moleculesISS:BHF-UCL
Cell-cell adhesion involved in synapse maturationIC:ComplexPortal
Cellular response to calcium ionISS:ARUK-UCL
Cerebellar granule cell differentiationISS:BHF-UCL
Establishment of protein localizationISS:BHF-UCL
Gamma-aminobutyric acid receptor clusteringISS:BHF-UCL
Gephyrin clustering involved in postsynaptic density assemblyISS:BHF-UCL
Guanylate kinase-associated protein clusteringISS:BHF-UCL
Heterophilic cell-cell adhesion via plasma membrane cell adhesion moleculesISS:BHF-UCL
LearningManual Assertion Based On ExperimentIMP:BHF-UCL
Maintenance of synapse structureIC:ComplexPortal
Negative regulation of filopodium assemblyISS:BHF-UCL
Negative regulation of gene expressionManual Assertion Based On ExperimentIDA:ARUK-UCL
Neuroligin clustering involved in postsynaptic membrane assemblyISS:BHF-UCL
Neuron cell-cell adhesionISS:BHF-UCL
Neuron projection developmentManual Assertion Based On ExperimentIGI:ARUK-UCL
Neuron projection morphogenesisIC:ComplexPortal
Neuronal signal transductionManual Assertion Based On ExperimentTAS:BHF-UCL
NMDA glutamate receptor clusteringISS:BHF-UCL
Positive regulation of ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of excitatory postsynaptic potentialISS:BHF-UCL
Positive regulation of fibroblast growth factor receptor signaling pathwayManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of gene expressionManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of neuromuscular synaptic transmissionIC:ComplexPortal
Positive regulation of neuron projection developmentIC:ComplexPortal
Positive regulation of peptidyl-serine phosphorylationManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of presynaptic active zone assemblyManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of protein kinase A signalingManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of protein kinase B signalingManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of protein kinase C activityManual Assertion Based On ExperimentIDA:ARUK-UCL
Positive regulation of protein localization to plasma membraneISS:BHF-UCL
Positive regulation of synapse assemblyManual Assertion Based On ExperimentTAS:BHF-UCL
Positive regulation of synaptic transmission, GABAergicIC:ComplexPortal
Positive regulation of synaptic transmission, glutamatergicISS:BHF-UCL
Postsynaptic density protein 95 clusteringISS:BHF-UCL
Postsynaptic membrane assemblyISS:BHF-UCL
Presynaptic membrane assemblyISS:BHF-UCL
Protein localization to synapseISS:BHF-UCL
Protein-containing complex assembly involved in synapse maturationISS:BHF-UCL
Receptor localization to synapseISS:BHF-UCL
Regulation of AMPA receptor activityISS:BHF-UCL
Regulation of NMDA receptor activityISS:BHF-UCL
Signal transductionISS:BHF-UCL
Social behaviorManual Assertion Based On ExperimentIMP:BHF-UCL
Synapse assemblyISS:BHF-UCL
Synapse maturationIC:ComplexPortal
Synaptic vesicle clusteringISS:BHF-UCL
Vocalization behaviorManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Cell junction, synapse, presynaptic cell membrane
Topology
Extracellular: 51-396
Helical: 397-417
Cytoplasmic: 418-472
PTM
Highly O-glycosylated and minor N-glycosylated.

Skiba, A., Talarowska, M., Szemraj, J., & Gałecki, P. (2021). Is NRXN1 Gene Expression an Important Marker of Treatment of Depressive Disorders? A Pilot Study. Journal of Personalized Medicine, 11(7), 637.

Zhang, S., Wu, D., Xu, Q., You, L., Zhu, J., Wang, J., ... & Chi, X. (2021). The protective effect and potential mechanism of NRXN1 on learning and memory in ADHD rat models. Experimental Neurology, 344, 113806.

Cosemans, N., Vandenhove, L., Vogels, A., Devriendt, K., Van Esch, H., Van Buggenhout, G., ... & Peeters, H. (2020). The clinical relevance of intragenic NRXN1 deletions. Journal of medical genetics, 57(5), 347-355.

Yotsumoto, T., Maemura, K., Watanabe, K., Amano, Y., Matsumoto, Y., Zokumasu, K., ... & Takai, D. (2020). NRXN1 as a novel potential target of antibody-drug conjugates for small cell lung cancer. Oncotarget, 11(39), 3590.

Castronovo, P., Baccarin, M., Ricciardello, A., Picinelli, C., Tomaiuolo, P., Cucinotta, F., ... & Persico, A. M. (2020). Phenotypic spectrum of NRXN1 mono‐and bi‐allelic deficiency: a systematic review. Clinical genetics, 97(1), 125-137.

Ishizuka, K., Yoshida, T., Kawabata, T., Imai, A., Mori, H., Kimura, H., ... & Ozaki, N. (2020). Functional characterization of rare NRXN1 variants identified in autism spectrum disorders and schizophrenia. Journal of neurodevelopmental disorders, 12, 1-16.

Hu, Z., Xiao, X., Zhang, Z., & Li, M. (2019). Genetic insights and neurobiological implications from NRXN1 in neuropsychiatric disorders. Molecular psychiatry, 24(10), 1400-1414.

Lam, M., Moslem, M., Bryois, J., Pronk, R. J., Uhlin, E., Ellström, I. D., ... & Falk, A. (2019). Single cell analysis of autism patient with bi-allelic NRXN1-alpha deletion reveals skewed fate choice in neural progenitors and impaired neuronal functionality. Experimental cell research, 383(1), 111469.

Al Shehhi, M., Forman, E. B., Fitzgerald, J. E., McInerney, V., Krawczyk, J., Shen, S., ... & Lynch, S. A. (2019). NRXN1 deletion syndrome; phenotypic and penetrance data from 34 families. European journal of medical genetics, 62(3), 204-209.

Alliey-Rodriguez, N., Grey, T. A., Shafee, R., Asif, H., Lutz, O., Bolo, N. R., ... & Gershon, E. S. (2019). NRXN1 is associated with enlargement of the temporal horns of the lateral ventricles in psychosis. Translational psychiatry, 9(1), 230.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
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