NSL1

NSL1 two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. There is a pseudogene of the 3' UTR region of this gene on chromosome X.

NSL1, MIS12 Kinetochore Complex Component

Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.

Cell divisionIEA:UniProtKB-KW
Mitotic sister chromatid segregationManual Assertion Based On ExperimentIBA:GO_Central

Nucleus
Chromosome, centromere, kinetochore
Associated with the kinetochore (PubMed:15502821, PubMed:16585270).