PARVB

Members of the parvin family, including PARVB, are actin-binding proteins associated with focal contacts.[supplied by OMIM

Full Name

parvin, beta

Function

Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.

Biological Process

Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIMP:UniProtKB
Cell projection assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Establishment or maintenance of cell polarity regulating cell shapeManual Assertion Based On ExperimentIMP:UniProtKB
Lamellipodium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell junction, focal adhesion
Cell membrane
Cytoplasm, cytoskeleton
Cell projection, lamellipodium
Cytoplasm, myofibril, sarcomere
Cytoplasm, myofibril, sarcomere, Z line
Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia.