Mouse Anti-PARVB Recombinant Antibody (1B9) (CBMAB-P0831-YC)

Name: Mouse Anti-PARVB Recombinant Antibody (1B9)
SKU: CBMAB-P0831-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

1B9

Application

WB, IHC, IF

Immunogen

Full length human recombinant protein of human PARVB(NP_037459) produced in HEK293T cell

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

parvin, beta

Introduction

PARVB is a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression.

Entrez Gene ID

29780

UniProt ID

Q9HBI1

Alternative Names

Parvin Beta; Affixin; Beta-Parvin; CGI-56;

Function

Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.

Biological Process

Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIMP:UniProtKB
Cell projection assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Establishment or maintenance of cell polarity regulating cell shapeManual Assertion Based On ExperimentIMP:UniProtKB
Lamellipodium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cell junction, focal adhesion
Cell membrane
Cytoplasm, cytoskeleton
Cell projection, lamellipodium
Cytoplasm, myofibril, sarcomere
Cytoplasm, myofibril, sarcomere, Z line
Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia.

Wang, T., Wu, Z., Bi, Y., Wang, Y., Zhao, C., Sun, H., ... & Yan, W. (2024). PARVB promotes malignant melanoma progression and is enhanced by hypoxic conditions. Translational Oncology, 42, 101861.

Liu, R., Shang, W., Liu, Y., Xie, Y., Luan, J., Zhang, T., ... & Han, F. (2024). Inhibition of the ILK-AKT pathway by upregulation of PARVB contributes to the cochlear cell death in Fascin2 gene knockout mice. Cell Death Discovery, 10(1), 89.

Lee, K. J., Moon, J. S., Lim, J. G., Huh, H., Ahn, J. E., Kim, L., ... & Ko, J. S. (2024). PARVB and HSD17B13 variants are associated with nonalcoholic fatty liver disease in children. Journal of Gastroenterology and Hepatology.

Thievessen, I., Suhr, F., Vergarajauregui, S., Böttcher, R. T., Brixius, K., Rosenberger, G., ... & Fässler, R. (2022). The focal adhesion protein β-parvin controls cardiomyocyte shape and sarcomere assembly in response to mechanical load. Current Biology, 32(14), 3033-3047.

Xu, K., Zheng, K. I., Zhu, P. W., Liu, W. Y., Ma, H. L., Li, G., ... & Zheng, M. H. (2022). Interaction of SAMM50-rs738491, PARVB-rs5764455 and PNPLA3-rs738409 increases susceptibility to nonalcoholic steatohepatitis. Journal of clinical and translational hepatology, 10(2), 219.

Yu, W., Wu, P., Wang, F., Miao, L., Han, B., & Jiang, Z. (2021). Construction of novel methylation-driven gene model and investigation of PARVB function in glioblastoma. Frontiers in Oncology, 11, 705547.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-PARVB Recombinant Antibody (4A11) (CAT#: CBMAB-P0833-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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