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Mouse Anti-PARVB Recombinant Antibody (4A11) (CBMAB-P0833-YC)

Provided herein is a Mouse monoclonal antibody against Human Parvin Beta. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PARVB antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4A11
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
PARVB (AAH46103, 1-350 aa) full length recombinant protein with GST tag. Immunogen sequence: MKKDESFLGK LGGTLARKRR AREVSDLQEE GKNAINSPMS PALADVHPED TQLEENEERT MIDPTSKEDP KFKELVKVLL DWINDVLVEE RIIVKQLEED LYDGQVLQKL LEKLAGCKLN VAEVTQSEIG QKQKLQTVLE AVHDLLRPRG WALRWSVDSI HGKNLVAILH LLVSLAMHFR APIRLPEHVT VQVVVVRKRE GLLHSSHISE ELTTTTEMMM GRFERDAFDT LFDHAPDKLS VVKKSLITFV NKHLNKLNLE VTELETQFAD GVYLVLLMGL LEDYFVPLHH FYLTPESFDQ KVHNVSFAFE LMLDGGLKKP KARPEDVVNL DLKSTLRVLY NLFTKYKNVE
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-350

Target

Full Name
parvin, beta
Introduction
PARVB is a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression.
Entrez Gene ID
29780
UniProt ID
Q9HBI1
Alternative Names
Parvin Beta; Affixin; Beta-Parvin; CGI-56;
Function
Adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases CDC42 and RAC1 by guanine exchange factors, such as ARHGEF6. Is involved in the reorganization of the actin cytoskeleton and formation of lamellipodia. Plays a role in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration.
Biological Process
Actin cytoskeleton reorganizationManual Assertion Based On ExperimentIMP:UniProtKB
Cell projection assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Establishment or maintenance of cell polarity regulating cell shapeManual Assertion Based On ExperimentIMP:UniProtKB
Lamellipodium assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Substrate adhesion-dependent cell spreadingManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cell junction, focal adhesion
Cell membrane
Cytoplasm, cytoskeleton
Cell projection, lamellipodium
Cytoplasm, myofibril, sarcomere
Cytoplasm, myofibril, sarcomere, Z line
Constituent of focal adhesions. Detected at the tips of the leading edge of cells. Colocalizes with F-actin at the tips of lamellipodia.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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