PCDHB6

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections. [provided by RefSeq]

Full Name

protocadherin beta 6

Function

Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain.

Biological Process

Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules1 PublicationNAS:UniProtKB
Cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell recognitionISS:UniProtKB
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:UniProtKB
Homophilic cell adhesion via plasma membrane adhesion moleculesISS:UniProtKB
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Synapse assemblyManual Assertion Based On ExperimentTAS:UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 28-688
Helical: 689-709
Cytoplasmic: 710-794