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Mouse Anti-PCDHB6 Recombinant Antibody (2G11) (CBMAB-P1012-YC)

Provided herein is a Mouse monoclonal antibody against Human Protocadherin Beta 6. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PCDHB6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2G11
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
PCDHB6 (NP_061762, 118-217 aa) partial recombinant protein with GST tag. Immunogen sequence: ASLRVRDIND HAPEFPAREM LLKISEITMP GKIFPLKMAH DLDTGSNGLQ RYTISSNPHF HVLTRNRSEG RKFPELVLDK PLDREEQPQL RLTLIALDGG
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 118-217

Target

Full Name
protocadherin beta 6
Introduction
PCDHB6 is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. Unlike the alpha and gamma clusters, the transcripts from these genes do not share common 3' exons. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell neural connections.
Entrez Gene ID
56130
UniProt ID
Q9Y5E3
Alternative Names
Protocadherin Beta 6; Protocadherin Beta-6; PCDH-Beta-6; PCDH-BETA6;
Function
Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination. Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain.
Biological Process
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules1 PublicationNAS:UniProtKB
Cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Cell-cell recognitionISS:UniProtKB
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:UniProtKB
Homophilic cell adhesion via plasma membrane adhesion moleculesISS:UniProtKB
Nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Synapse assemblyManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Cell membrane
Topology
Extracellular: 28-688
Helical: 689-709
Cytoplasmic: 710-794
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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