PCDHGA3

PCDHGA3 is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

Full Name

Protocadherin Gamma Subfamily A, 3

Function

Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.

Biological Process

Cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Endosome to lysosome transportIEA:Ensembl
Homophilic cell adhesion via plasma membrane adhesion moleculesIEA:InterPro
Lipid tube assembly involved in organelle fusionIEA:Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 30-692
Helical: 693-713
Cytoplasmic: 714-932