PCDHGA3

PCDHGA3 is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
Full Name
Protocadherin Gamma Subfamily A, 3
Function
Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain.
Biological Process
Cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Endosome to lysosome transportIEA:Ensembl
Homophilic cell adhesion via plasma membrane adhesion moleculesIEA:InterPro
Lipid tube assembly involved in organelle fusionIEA:Ensembl
Cellular Location
Cell membrane
Topology
Extracellular: 30-692
Helical: 693-713
Cytoplasmic: 714-932
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Anti-PCDHGA3 antibodies

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Mouse Anti-PCDHGA3 Recombinant Antibody (S159-5) (CBMAB-P1022-YC)

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Target: PCDHGA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse, Rat
Clone: S159-5
Application*: WB, P
Datasheet SDS

Mouse Anti-PCDHGA3 Recombinant Antibody (S144-32) (CBMAB-P1021-YC)

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Target: PCDHGA3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Mouse, Rat
Clone: S144-32
Application*: WB, IF, IC
Datasheet SDS

Mouse Anti-PCDHGA3 Recombinant Antibody (S144-17) (CBMAB-P1020-YC)

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Target: PCDHGA3
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: S144-17
Application*: IC, WB
Datasheet SDS

Mouse Anti-PCDHGA3 Recombinant Antibody (G-5) (CBMAB-P1019-YC)

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Target: PCDHGA3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: G-5
Application*: WB, IP, IF, E
Datasheet SDS

Human PCDHGA3 ELISA Kit (V2LY-0626-LY5135)

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Target: PCDHGA3
Sensitivity: 0.0096 ng/mL
Detection Range: 0.02-7 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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