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PEPD

This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

Full Name

Peptidase D

Function

Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen.

Biological Process

Cellular amino acid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Collagen catabolic processIEA:UniProtKB-KW
ProteolysisManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Extracellular exosome

Involvement in disease

Prolidase deficiency (PD):
A multisystem disorder associated with massive iminodipeptiduria and lack of or reduced prolidase activity in erythrocytes, leukocytes, or cultured fibroblasts. Clinical features include skin ulcers, developmental delay, recurrent infections, and a characteristic facies.

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Anti-PEPD antibodies

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Mouse Anti-PEPD Recombinant Antibody (4A5-D10) (CBMAB-P1451-YC)

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Target: PEPD

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 4A5-D10

Application*: E

Mouse Anti-PEPD Recombinant Antibody (5D5) (CBMAB-P1452-YC)

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Target: PEPD

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 5D5

Application*: WB, F

Mouse Anti-PEPD Recombinant Antibody (1D5-H3) (CBMAB-P1450-YC)

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Target: PEPD

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1D5-H3

Application*: IF, WB

Mouse Anti-PEPD Recombinant Antibody (1B7) (CBMAB-P1449-YC)

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Target: PEPD

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1B7

Application*: F, IC, IF, IH, P, WB

PEPD Matched Antibody Pair (867) (APMAB-867LY)

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Target: PEPD

Specificity: Human

PEPD Matched Antibody Pair (866) (APMAB-866LY)

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Target: PEPD

Specificity: Human

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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