PEPD

This gene encodes a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di- and tri-peptides containing proline. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Full Name
Peptidase D
Function
Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen.
Biological Process
Cellular amino acid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Collagen catabolic processIEA:UniProtKB-KW
ProteolysisManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Extracellular exosome
Involvement in disease
Prolidase deficiency (PD):
A multisystem disorder associated with massive iminodipeptiduria and lack of or reduced prolidase activity in erythrocytes, leukocytes, or cultured fibroblasts. Clinical features include skin ulcers, developmental delay, recurrent infections, and a characteristic facies.
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Anti-PEPD antibodies

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Mouse Anti-PEPD Recombinant Antibody (4A5-D10) (CBMAB-P1451-YC)

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Target: PEPD
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4A5-D10
Application*: E
Datasheet SDS

Mouse Anti-PEPD Recombinant Antibody (5D5) (CBMAB-P1452-YC)

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Target: PEPD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5D5
Application*: WB, F
Datasheet SDS

Mouse Anti-PEPD Recombinant Antibody (1D5-H3) (CBMAB-P1450-YC)

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Target: PEPD
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1D5-H3
Application*: IF, WB
Datasheet SDS

Mouse Anti-PEPD Recombinant Antibody (1B7) (CBMAB-P1449-YC)

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Target: PEPD
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B7
Application*: F, IC, IF, IH, P, WB
Datasheet SDS

PEPD Matched Antibody Pair (867) (APMAB-867LY)

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Target: PEPD
Specificity: Human
Datasheet SDS

PEPD Matched Antibody Pair (866) (APMAB-866LY)

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Target: PEPD
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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