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Mouse Anti-PEPD Recombinant Antibody (4A5-D10) (CBMAB-P1451-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4A5-D10
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
PEPD (AAH15027, 1-493 aa) full length recombinant protein with GST tag. Immunogen sequence: MAAATGPSFW LGNETLKVPL ALFALNRQRL CERLRKNPAV QAGSIVVLQG GEETQRYCTD TGVLFRQESF FHWAFGVAEP GCYGVIDVDT GKSTLFVPRL PASHATWMGK IHSKEHFKEK YAVDDVQYVD EIASVLTSQE PSVLLTLRGV NTDSGSVCRE ASFDGISKFE VNNTILHPEI VECRVFKTDM ELEVLRYTNK ISSEAHREVM KAVKVGMKEY ELESLFEHYC YSRGGMRHSS YTCICGSGEN SAVLHYGHAG APNDRTIQNG DMCLFDMGGE YYCFASDITC SFPANGKFTA DQKAVYEAVL RSSRAVMGAM KPGVWWPDMH RLADRIHLEE LAHMGILSGS VDAMVQAHLG AVFMPHGLGH FLGIDVHDVG GYPEGVERID EPGLRSLRTA RHLQPGMVLT VEPGIYFIDH LLDEALADPA RASFLNREVL QRFRGFGGVR IEEDVVVTDS GIELLTCVPR TVEEIEACMA GCDKAFTPFS GPK
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-493

Target

Full Name
Peptidase D
Introduction
PEPD is a member of the peptidase family. The protein forms a homodimer that hydrolyzes dipeptides or tripeptides with C-terminal proline or hydroxyproline residues. The enzyme serves an important role in the recycling of proline, and may be rate limiting for the production of collagen. Mutations in this gene result in prolidase deficiency, which is characterized by the excretion of large amount of di-and tri-peptides containing proline.
Entrez Gene ID
5184
UniProt ID
P12955
Alternative Names
Peptidase D; Prolidase; Proline Dipeptidase; X-Pro Dipeptidase; Imidodipeptidase; Testicular Tissue Protein Li 138;
Function
Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because the high level of iminoacids in collagen.
Biological Process
Cellular amino acid metabolic processManual Assertion Based On ExperimentTAS:ProtInc
Collagen catabolic processIEA:UniProtKB-KW
ProteolysisManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Extracellular exosome
Involvement in disease
Prolidase deficiency (PD):
A multisystem disorder associated with massive iminodipeptiduria and lack of or reduced prolidase activity in erythrocytes, leukocytes, or cultured fibroblasts. Clinical features include skin ulcers, developmental delay, recurrent infections, and a characteristic facies.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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