PFDN5

PFDN5 is a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described.

Full Name

Prefoldin Subunit 5

Function

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC.

Biological Process

Negative regulation of amyloid fibril formationManual Assertion Based On ExperimentIDA:FlyBase
Negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:BHF-UCL
Protein foldingManual Assertion Based On ExperimentIDA:FlyBase
Protein stabilization1 PublicationIC:ComplexPortal
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIBA:GO_Central
Retina development in camera-type eyeIEA:Ensembl

Cellular Location

Isoform 1
Nucleus
Isoform 2
Cytoplasm
Isoform 3
Nucleus