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PFKFB3

The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]
Full Name
6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3
Function
Catalyzes both the synthesis and degradation of fructose 2,6-bisphosphate.
Biological Process
Brain developmentIEA:Ensembl
Fructose 2,6-bisphosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Fructose metabolic processIEA:InterPro
Cellular Location
cytosol
nucleoplasm
PTM
Phosphorylation by AMPK stimulates activity.
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Anti-PFKFB3 antibodies

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Mouse Anti-PFKFB3 Recombinant Antibody (A-1) (CBMAB-P1507-YC)

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Target: PFKFB3
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A-1
Application*: WB, IP, IF, E
Datasheet SDS

Rabbit Anti-PFKFB3 Recombinant Antibody (D7H4Q) (CBMAB-CP1940-LY)

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Target: PFKFB3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: D7H4Q
Application*: WB
Datasheet SDS

Rabbit Anti-PFKFB3 Recombinant Antibody (CBYC-P308) (CBMAB-P1509-YC)

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Target: PFKFB3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-P308
Application*: IC, IF
Datasheet SDS

Rabbit Anti-PFKFB3 Recombinant Antibody (D7G5R) (CBMAB-P1508-YC)

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Target: PFKFB3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: D7G5R
Application*: WB, IP, IF
Datasheet SDS

Mouse Anti-PFKFB3 Recombinant Antibody (3F3) (CBMAB-P1506-YC)

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Target: PFKFB3
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3F3
Application*: E, IP, WB
Datasheet SDS

Rabbit Anti-PFKFB3 Recombinant Antibody (BA0110) (CBMAB-0620CQ)

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Target: PFKFB3
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: BA0110
Application*: F, IF, P, IP, WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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