PFKFB3

The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2016]

6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3

Catalyzes both the synthesis and degradation of fructose 2,6-bisphosphate.

Brain developmentIEA:Ensembl
Fructose 2,6-bisphosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Fructose metabolic processIEA:InterPro

cytosol
nucleoplasm

Phosphorylation by AMPK stimulates activity.