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Rabbit Anti-PFKFB3 Recombinant Antibody (BA0110) (CBMAB-0620CQ)

This product is a rabbit antibody that recognizes PFKFB3. The antibody BA0110 can be used for immunoassay techniques such as: FC, IF, IHC-P, IP, WB.
See all PFKFB3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
BA0110
Antibody Isotype
IgG
Application
FC, IF, IHC-P, IP, WB

Basic Information

Immunogen
Human PFKFB3 aa 300 to the C-terminus
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3
Introduction
The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. Diseases associated with PFKFB3 include Colon Adenocarcinoma. Among its related pathways are Akt Signaling and Metabolism. GO annotations related to this gene include 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. An important paralog of this gene is PFKFB2.
Entrez Gene ID
Human5209
Mouse170768
Rat117276
UniProt ID
HumanQ16875
MouseQ3U3S6
RatO35552
Alternative Names
PFK2; IPFK2; iPFK-2
Function
Catalyzes both the synthesis and degradation of fructose 2,6-bisphosphate.
Biological Process
Brain developmentIEA:Ensembl
Fructose 2,6-bisphosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Fructose metabolic processIEA:InterPro
Cellular Location
cytosol
nucleoplasm
PTM
Phosphorylation by AMPK stimulates activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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