Sign in or Register   Sign in or Register
  |  

Rabbit Anti-PFKFB3 Recombinant Antibody (D7G5R) (CBMAB-P1508-YC)

Provided herein is a Rabbit monoclonal antibody against Human 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3. The antibody can be used for immunoassay techniques, such as WB, IP, IF.
See all PFKFB3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
D7G5R
Antibody Isotype
IgG
Application
WB, IP, IF

Basic Information

Specificity
Human, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3
Introduction
PFKFB3 belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several
Entrez Gene ID
Human5209
Monkey713062
UniProt ID
HumanQ16875
MonkeyF7CGA9
Alternative Names
6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3; PF-2-K/Fru-2,6-P2ase Brain/Placenta-Type Isozyme; Renal Carcinoma Antigen NY-REN-56; PF-2-K/Fru-2,6-P2ase 3; PFK/FBPase 3; IPFK-2; Inducible 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase;
Function
Catalyzes both the synthesis and degradation of fructose 2,6-bisphosphate.
Biological Process
Brain developmentIEA:Ensembl
Fructose 2,6-bisphosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Fructose metabolic processIEA:InterPro
Cellular Location
cytosol
nucleoplasm
PTM
Phosphorylation by AMPK stimulates activity.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Rabbit Anti-PFKFB3 Recombinant Antibody (D7G5R)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare