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Mouse Anti-PFKFB3 Recombinant Antibody (A-1) (CBMAB-P1507-YC)

Provided herein is a Mouse monoclonal antibody against Human 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3. The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all PFKFB3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
A-1
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3
Introduction
PFKFB3 belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several
Entrez Gene ID
5209
UniProt ID
Q16875
Alternative Names
6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3; PF-2-K/Fru-2,6-P2ase Brain/Placenta-Type Isozyme; Renal Carcinoma Antigen NY-REN-56; PF-2-K/Fru-2,6-P2ase 3; PFK/FBPase 3; IPFK-2; Inducible 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase;
Function
Catalyzes both the synthesis and degradation of fructose 2,6-bisphosphate.
Biological Process
Brain developmentIEA:Ensembl
Fructose 2,6-bisphosphate metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Fructose metabolic processIEA:InterPro
Cellular Location
cytosol
nucleoplasm
PTM
Phosphorylation by AMPK stimulates activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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