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PGA3

PGA3 is a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer.

Full Name

Pepsinogen 3, Group I (Pepsinogen A)

Function

Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.

Biological Process

DigestionIEA:UniProtKB-KW

Cellular Location

Secreted

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Anti-PGA3 antibodies

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Mouse Anti-PGA3 Recombinant Antibody (L10CC10) (CBMAB-P1533-YC)

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Target: PGA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: L10CC10

Application*: E, P, WB

Mouse Anti-PGA3 Recombinant Antibody (90/10) (CBMAB-P1532-YC)

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Target: PGA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 90/10

Application*: E

Mouse Anti-PGA3 Recombinant Antibody (4C6.1) (CBMAB-P1531-YC)

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Target: PGA3

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4C6.1

Application*: E, IH, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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