PGA5

This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer. [provided by RefSeq, Jul 2015]
Full Name
Pepsinogen 5, Group I (Pepsinogen A)
Function
Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent.
Biological Process
DigestionIEA:UniProtKB-KW
Cellular Location
Secreted
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Anti-PGA5 antibodies

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Mouse Anti-PGA5 Recombinant Antibody (CBYC-P315) (CBMAB-P1542-YC)

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Target: PGA5
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYC-P315
Application*: E, WB
Datasheet SDS

Mouse Anti-PGA5 Recombinant Antibody (C4) (CBMAB-P1541-YC)

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Target: PGA5
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: C4
Application*: WB, IC, P, C, E, IP, IF, F
Datasheet SDS

Mouse Anti-PGA5 Recombinant Antibody (4G9) (CBMAB-P1540-YC)

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Target: PGA5
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4G9
Application*: WB
Datasheet SDS

Mouse Anti-PGA5 Recombinant Antibody (2C1) (CBMAB-P1539-YC)

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Target: PGA5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2C1
Application*: E, IH, P, WB
Datasheet SDS

Mouse Anti-PGA5 Recombinant Antibody (13B618) (CBMAB-P1538-YC)

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Target: PGA5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13B618
Application*: E, IH, WB
Datasheet SDS

Mouse Anti-PGA5 Recombinant Antibody (CBT4580) (V2LY-0625-LY2378)

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Target: PGA5
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4580
Application*: WB, IH
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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