PGAM5

PGAM5 has ubiquitous expression in esophagus (RPKM 6.8), testis (RPKM 6.7) and 25 other tissues.

Full Name

PGAM Family Member 5, Mitochondrial Serine/Threonine Protein Phosphatase

Function

Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore.

Biological Process

MacroautophagyTAS:Reactome
Necroptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Peptidyl-threonine dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of mitochondrial fissionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Mitochondrion outer membrane
Isoform 2 overexpression results in the formation of disconnected punctuate mitochondria distributed throughout the cytoplasm. Isoform 1 overexpression results in the clustering of mitochondria around the nucleus.

Topology

Helical: 7-29

PTM

Both isoform 1 and isoform 2 are phosphorylated by the RIPK1/RIPK3 complex under necrotic conditions. This phosphorylation increases PGAM5 phosphatase activity.