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Mouse Anti-PGAM5 Recombinant Antibody (CL0624) (CBMAB-P1551-YC)

Provided herein is a Mouse monoclonal antibody against Human PGAM Family Member 5, Mitochondrial Serine/Threonine Protein Phosphatase. The antibody can be used for immunoassay techniques, such as IHC, WB.
See all PGAM5 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CL0624
Antibody Isotype
IgG1
Application
IHC, WB

Basic Information

Immunogen
Recombinant protein corresponding to Human PGAM5
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS with 40% glycerol and 0.02% sodium azide, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
PGAM Family Member 5, Mitochondrial Serine/Threonine Protein Phosphatase
Introduction
PGAM5 has ubiquitous expression in esophagus (RPKM 6.8), testis (RPKM 6.7) and 25 other tissues.
Entrez Gene ID
192111
UniProt ID
Q96HS1
Alternative Names
PGAM Family Member 5, Mitochondrial Serine/Threonine Protein Phosphatase; Phosphoglycerate Mutase Family Member 5; PGAM Family Member 5, Serine/Threonine Protein Phosphatase, Mitochondrial; Bcl-XL-Binding Protein V68; Serine/Threonine-Protein Phosphatase PGAM5, Mitochondrial; EC 3.1.3.16; BXLBV68;
Function
Displays phosphatase activity for serine/threonine residues, and, dephosphorylates and activates MAP3K5 kinase. Has apparently no phosphoglycerate mutase activity. May be regulator of mitochondrial dynamics. Substrate for a KEAP1-dependent ubiquitin ligase complex. Contributes to the repression of NFE2L2-dependent gene expression. Acts as a central mediator for programmed necrosis induced by TNF, by reactive oxygen species and by calcium ionophore.
Biological Process
MacroautophagyTAS:Reactome
Necroptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Peptidyl-threonine dephosphorylationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of mitochondrial fissionManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Mitochondrion outer membrane
Isoform 2 overexpression results in the formation of disconnected punctuate mitochondria distributed throughout the cytoplasm. Isoform 1 overexpression results in the clustering of mitochondria around the nucleus.
Topology
Helical: 7-29
PTM
Both isoform 1 and isoform 2 are phosphorylated by the RIPK1/RIPK3 complex under necrotic conditions. This phosphorylation increases PGAM5 phosphatase activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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