PHM

PHM belongs to the glucagon secretin family of peptide hormones and like VIP is a vasodilator and stimulator of intestinal fluid secretion. all pro VIP derived neuropeptides are frequently colocalized, but appear to exert different physiological effects. The VIP/PHM prohormone is produced by neurons in the central and peripheral nervous systems, often together with acetylcholine.

Full Name

Peptide histidine methionine

Function

VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.
PHM and PHV also cause vasodilation. PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIDA:BHF-UCL
Antibacterial humoral responseIDA:UniProtKB
Antifungal humoral responseIDA:UniProtKB
Antimicrobial humoral immune response mediated by antimicrobial peptideIDA:UniProtKB
Body fluid secretionManual Assertion Based On ExperimentTAS:ProtInc
Defense response to Gram-negative bacteriumIDA:UniProtKB
Defense response to Gram-positive bacteriumIDA:UniProtKB
Epinephrine secretionManual Assertion Based On ExperimentIBA:GO_Central
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Innate immune responseIDA:UniProtKB
Learning or memoryManual Assertion Based On ExperimentIBA:GO_Central
mRNA stabilizationISS:AgBase
Negative regulation of apoptotic processManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of potassium ion transportManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of smooth muscle cell proliferationManual Assertion Based On ExperimentIBA:GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cell population proliferationManual Assertion Based On ExperimentTAS:ProtInc
Positive regulation of endothelial cell proliferationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of epinephrine secretionManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of penile erectionManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of protein catabolic processManual Assertion Based On ExperimentIDA:BHF-UCL
Prolactin secretionISS:AgBase
Regulation of protein localizationManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of sensory perception of painManual Assertion Based On ExperimentIBA:GO_Central
Response to yeastIDA:UniProtKB

Cellular Location

Secreted