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PHPT1

PHPT1 is an enzyme that catalyzes the reversible dephosphorylation of histidine residues in proteins. It may be involved in the dephosphorylation of G-beta and ATP citrate lyase and in negatively regulating CD4 T lymphocytes by dephosphorylation and inhibition of KCa3.1 channels.

Full Name

Phosphohistidine Phosphatase 1

Function

Exhibits phosphohistidine phosphatase activity.

Biological Process

Negative regulation of ATP citrate synthase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of lyase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Negative regulation of T cell receptor signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Peptidyl-histidine dephosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of cell motilityManual Assertion Based On ExperimentIMP:BHF-UCL
Protein dephosphorylationManual Assertion Based On ExperimentIDA:BHF-UCL
Regulation of actin cytoskeleton reorganizationManual Assertion Based On ExperimentIMP:BHF-UCL

Cellular Location

Cytoplasm

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Anti-PHPT1 antibodies

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Mouse Anti-PHPT1 Recombinant Antibody (C-6) (CBMAB-P1713-YC)

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Target: PHPT1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: C-6

Application*: WB, IP, IF, E

Rabbit Anti-PHPT1 Recombinant Antibody (001) (CBMAB-P1712-YC)

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Target: PHPT1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 001

Application*: IH, IC, IF

Human Recombinant PHPT1 protein, His Tag (V2LY-0526-LY6149)

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Target: PHPT1

Expressed Host: E. coli

Sequence: Amino Acid: 2-125

Tag: His Tag

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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