PI4K2A

Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo-and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs.

Full Name

Phosphatidylinositol 4-Kinase Type 2 Alpha

Function

Membrane-bound phosphatidylinositol-4 kinase (PI4-kinase) that catalyzes the phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P), a lipid that plays important roles in endocytosis, Golgi function, protein sorting and membrane trafficking and is required for prolonged survival of neurons. Besides, phosphorylation of phosphatidylinositol (PI) to phosphatidylinositol 4-phosphate (PI4P) is the first committed step in the generation of phosphatidylinositol 4,5-bisphosphate (PIP2), a precursor of the second messenger inositol 1,4,5-trisphosphate (InsP3).

Biological Process

Endosome organizationManual Assertion Based On ExperimentIBA:GO_Central
Golgi organizationManual Assertion Based On ExperimentIBA:GO_Central
Phosphatidylinositol biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
Phosphatidylinositol phosphate biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Golgi apparatus, trans-Golgi network membrane
Membrane raft
Cell projection, dendrite
Cell junction, synapse, presynaptic cell membrane
Cell junction, synapse, synaptosome
Mitochondrion
Endosome
Cytoplasmic vesicle
Membrane
Cell membrane
Perikaryon
Cell projection, neuron projection
Found in subdomains of the plasma membrane termed non-caveolar membrane rafts. Transported from neuronal cell body to neuron projections and neurite tips in a BLOC-1- and AP-3-complexes-dependent manner.

PTM

Palmitoylated by ZDHHC3 and ZDHHC7 in the CCPCC motif. Palmitoylation is cholesterol-dependent, and required for TGN localization.
Ubiquitinated by ITCH; this does not lead to proteasomal degradation.