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PILRB

The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function.

Full Name

Paired Immunoglobin-Like Type 2 Receptor Beta

Function

Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.

Biological Process

Activation of transmembrane receptor protein tyrosine kinase activity1 PublicationNAS:UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB

Cellular Location

Membrane

Topology

Extracellular: 20-191
Helical: 192-212
Cytoplasmic: 213-227

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Anti-PILRB antibodies

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Rat Anti-PILRB Recombinant Antibody (7H89) (CBMAB-P1842-YC)

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Target: PILRB

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: 7H89

Application*: E, F, WB

Rat Anti-PILRB Recombinant Antibody (11C43) (CBMAB-P1841-YC)

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Target: PILRB

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human

Clone: 11C43

Application*: F

Mouse Recombinant PILRB protein, hFc Tag (V2LY-0526-LY8781)

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Target: PILRB

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 1-193

Tag: hFc Tag

Human Recombinant PILRB protein, His Tag (V2LY-0526-LY6185)

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Target: PILRB

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 20-189

Tag: His Tag

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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