PILRB

The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function.
Full Name
Paired Immunoglobin-Like Type 2 Receptor Beta
Function
Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.
Biological Process
Activation of transmembrane receptor protein tyrosine kinase activity1 PublicationNAS:UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Membrane
Topology
Extracellular: 20-191
Helical: 192-212
Cytoplasmic: 213-227
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Anti-PILRB antibodies

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Rat Anti-PILRB Recombinant Antibody (7H89) (CBMAB-P1842-YC)

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Target: PILRB
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: 7H89
Application*: E, F, WB
Rat Anti-PILRB Recombinant Antibody (7H89)
Datasheet SDS

Rat Anti-PILRB Recombinant Antibody (11C43) (CBMAB-P1841-YC)

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Target: PILRB
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 11C43
Application*: F
Rat Anti-PILRB Recombinant Antibody (11C43)
Datasheet SDS

Mouse Recombinant PILRB protein, hFc Tag (V2LY-0526-LY8781)

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Target: PILRB
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-193
Tag: hFc Tag
Mouse Recombinant PILRB protein, hFc Tag
Datasheet SDS

Human Recombinant PILRB protein, His Tag (V2LY-0526-LY6185)

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Target: PILRB
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 20-189
Tag: His Tag
Human Recombinant PILRB protein, His Tag
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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