Rat Anti-PILRB Recombinant Antibody (7H89) (CBMAB-P1842-YC)

Name: Rat Anti-PILRB Recombinant Antibody (7H89)
SKU: CBMAB-P1842-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rat

Clone

7H89

Application

ELISA, FC, WB

Immunogen

NS0-derived recombinant mouse PIR-B (aa24-635

Specificity

Mouse

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

PBS with 5% trehalose

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Paired Immunoglobin-Like Type 2 Receptor Beta

Introduction

The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function.

Entrez Gene ID

170741

UniProt ID

Q2YFS2

Alternative Names

Paired Immunoglobin-Like Type 2 Receptor Beta; Activating Receptor PILR-Beta; Cell Surface Receptor FDFACT; Paired Immunoglobulin-Like Type 2 Receptor Beta; Paired Immunoglobulin-Like Receptor Beta; Paired Immunoglobin-Like Receptor Beta; Cell Surface Receptor FDFACT1;

Function

Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.

Biological Process

Activation of transmembrane receptor protein tyrosine kinase activity1 PublicationNAS:UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB

Cellular Location

Membrane

Topology

Extracellular: 20-191
Helical: 192-212
Cytoplasmic: 213-227

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Rat Anti-PILRB Recombinant Antibody (11C43) (CAT#: CBMAB-P1841-YC)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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