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Rat Anti-PILRB Recombinant Antibody (11C43) (CBMAB-P1841-YC)


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Summary

Host Animal
Rat
Specificity
Human
Clone
11C43
Antibody Isotype
IgG2a
Application
FC

Basic Information

Immunogen
Recombinant protein corresponding to aa24-635 from mouse PIR-B expressed in NS0 cells (Accession AAH26937)
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
0.5% BSA, 0.09% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction
The paired immunoglobin-like type 2 receptors consist of highly related activating and inhibitory receptors that are involved in the regulation of many aspects of the immune system. The paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This gene encodes the activating member of the receptor pair and contains a truncated cytoplasmic tail relative to its inhibitory counterpart (PILRA), that has a long cytoplasmic tail with immunoreceptor tyrosine-based inhibitory (ITIM) motifs. This gene is thought to have arisen from a duplication of the inhibitory PILRA gene and evolved to acquire its activating function.
Entrez Gene ID
29990
UniProt ID
Q9UKJ0
Alternative Names
Paired Immunoglobin-Like Type 2 Receptor Beta; Activating Receptor PILR-Beta; Cell Surface Receptor FDFACT; Paired Immunoglobulin-Like Type 2 Receptor Beta; Paired Immunoglobulin-Like Receptor Beta; Paired Immunoglobin-Like Receptor Beta; Cell Surface Receptor FDFACT1;
Function
Paired receptors consist of highly related activating and inhibitory receptors and are widely involved in the regulation of the immune system. PILRB is thought to act as a cellular signaling activating receptor that associates with ITAM-bearing adapter molecules on the cell surface.
Biological Process
Activation of transmembrane receptor protein tyrosine kinase activity1 PublicationNAS:UniProtKB
Transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Membrane
Topology
Extracellular: 20-191
Helical: 192-212
Cytoplasmic: 213-227
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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