PLA2G4B

This gene transcribes naturally-occurring mRNAs that are co-transcribed products of the neighboring JMJD7 and PLA2G4B genes. Incompletely processed read-through transcripts from these two loci are abundantly expressed in most tissues, but the function of the predicted protein product has not yet been determined. Alternative splicing of this gene results in different transcript variants, some of which are candidates for nonsense-mediated decay (NMD). [provided by RefSeq]

Full Name

JMJD7-PLA2G4B readthrough transcript

Function

Calcium-dependent phospholipase A1 and A2 and lysophospholipase that may play a role in membrane phospholipid remodeling.
Isoform 3
Calcium-dependent phospholipase A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-2 position of phosphatidylethanolamines, producing lysophospholipids that may be used in deacylation-reacylation cycles. Hydrolyzes lysophosphatidylcholines with low efficiency but is inefficient toward phosphatidylcholines.
Isoform 5
Calcium-dependent phospholipase A1 and A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-1 or sn-2 position of diacyl phospholipids (phospholipase A1 and A2 activity, respectively), producing lysophospholipids that may be used in deacylation-reacylation cycles. Can further hydrolyze lysophospholipids enabling complete deacylation. Has no activity toward alkylacyl phospholipids.

Biological Process

Arachidonic acid metabolic process1 PublicationNAS:UniProtKB
Calcium-mediated signaling1 PublicationNAS:UniProtKB
Glycerophospholipid catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory response1 PublicationNAS:UniProtKB
Parturition1 PublicationNAS:UniProtKB
Phosphatidylcholine acyl-chain remodelingIDA:UniProtKB
Phosphatidylethanolamine acyl-chain remodelingIDA:UniProtKB
Phosphatidylglycerol acyl-chain remodelingTAS:Reactome

Cellular Location

Isoform 3
Cytoplasm, cytosol
Mitochondrion membrane
Early endosome membrane
Translocates to membrane vesicles in a calcium-dependent fashion.
Isoform 5
Cytoplasm, cytosol