Mouse Anti-PLA2G4B Recombinant Antibody (1G5) (CBMAB-A6771-LY)

Name: Mouse Anti-PLA2G4B Recombinant Antibody (1G5)
SKU: CBMAB-A6771-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

1G5

Application

WB, ELISA

Immunogen

PLA2G4B (AAH25290.1, 1 a.a. ~ 316 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

JMJD7-PLA2G4B readthrough transcript

Introduction

This gene transcribes naturally-occurring mRNAs that are co-transcribed products of the neighboring JMJD7 and PLA2G4B genes. Incompletely processed read-through transcripts from these two loci are abundantly expressed in most tissues, but the function of the predicted protein product has not yet been determined. Alternative splicing of this gene results in different transcript variants, some of which are candidates for nonsense-mediated decay (NMD). [provided by RefSeq]

Entrez Gene ID

8681

UniProt ID

P0C869

Alternative Names

HsT16992; PLA2G4B; cPLA2-beta

Function

Calcium-dependent phospholipase A1 and A2 and lysophospholipase that may play a role in membrane phospholipid remodeling.
Isoform 3
Calcium-dependent phospholipase A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-2 position of phosphatidylethanolamines, producing lysophospholipids that may be used in deacylation-reacylation cycles. Hydrolyzes lysophosphatidylcholines with low efficiency but is inefficient toward phosphatidylcholines.
Isoform 5
Calcium-dependent phospholipase A1 and A2 and lysophospholipase. Cleaves the ester bond of the fatty acyl group attached to the sn-1 or sn-2 position of diacyl phospholipids (phospholipase A1 and A2 activity, respectively), producing lysophospholipids that may be used in deacylation-reacylation cycles. Can further hydrolyze lysophospholipids enabling complete deacylation. Has no activity toward alkylacyl phospholipids.

Biological Process

Arachidonic acid metabolic process1 PublicationNAS:UniProtKB
Calcium-mediated signaling1 PublicationNAS:UniProtKB
Glycerophospholipid catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Inflammatory response1 PublicationNAS:UniProtKB
Parturition1 PublicationNAS:UniProtKB
Phosphatidylcholine acyl-chain remodelingIDA:UniProtKB
Phosphatidylethanolamine acyl-chain remodelingIDA:UniProtKB
Phosphatidylglycerol acyl-chain remodelingTAS:Reactome

Cellular Location

Isoform 3
Cytoplasm, cytosol
Mitochondrion membrane
Early endosome membrane
Translocates to membrane vesicles in a calcium-dependent fashion.
Isoform 5
Cytoplasm, cytosol

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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