PLD1

Phosphatidylcholine (PC)-specific phospholipases D (PLDs; EC 3.1.4.4) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. A range of agonists acting through G protein-coupled receptors and receptor tyrosine kinases stimulate this hydrolysis. PC-specific PLD activity has been implicated in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis (Hammond et al., 1995 [PubMed 8530346]).[supplied by OMIM

Full Name

phospholipase D1, phosphatidylcholine-specific

Function

Function as phospholipase selective for phosphatidylcholine (PubMed:8530346, PubMed:9582313).
Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).

Biological Process

ChemotaxisManual Assertion Based On ExperimentTAS:ProtInc
Inositol lipid-mediated signalingIEA:InterPro
Phosphatidic acid biosynthetic processTAS:Reactome
Phospholipid catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of translationManual Assertion Based On ExperimentIMP:CACAO
Ras protein signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Regulation of microvillus assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of synaptic vesicle cycleManual Assertion Based On ExperimentIDA:SynGO
Regulation of vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Small GTPase mediated signal transductionManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm, perinuclear region
Endoplasmic reticulum membrane
Golgi apparatus membrane
Late endosome membrane

Involvement in disease

Cardiac valvular defect, developmental (CVDD):
An autosomal recessive form of congenital heart defects, characterized by valvular malformations involving the pulmonic, tricuspid and mitral valves.