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Mouse Anti-PLD1 Recombinant Antibody (10H2) (CBMAB-P2073-YC)

Provided herein is a Mouse monoclonal antibody against Human Phospholipase D1. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all PLD1 antibodies
Published Data
Fig. 1 PLD1 protein in cell extracts was analyzed by western blotting.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
10H2
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
PLD1 (NP_002653, 965-1075 aa) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
phospholipase D1, phosphatidylcholine-specific
Introduction
PLD1 is a phosphatidylcholine-specific phospholipase which catalyzes the hydrolysis of phosphatidylcholine in order to yield phosphatidic acid and choline. The enzyme may play a role in signal transduction and subcellular trafficking.
Entrez Gene ID
5337
UniProt ID
Q13393
Alternative Names
HPLD1; Phospholipase D1, Phosphatidylcholine-Specific
Function
Function as phospholipase selective for phosphatidylcholine (PubMed:8530346, PubMed:9582313).
Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).
Biological Process
ChemotaxisManual Assertion Based On ExperimentTAS:ProtInc
Inositol lipid-mediated signalingIEA:InterPro
Phosphatidic acid biosynthetic processTAS:Reactome
Phospholipid catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of translationManual Assertion Based On ExperimentIMP:CACAO
Ras protein signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Regulation of microvillus assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of synaptic vesicle cycleManual Assertion Based On ExperimentIDA:SynGO
Regulation of vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Small GTPase mediated signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm, perinuclear region
Endoplasmic reticulum membrane
Golgi apparatus membrane
Late endosome membrane
Involvement in disease
Cardiac valvular defect, developmental (CVDD):
An autosomal recessive form of congenital heart defects, characterized by valvular malformations involving the pulmonic, tricuspid and mitral valves.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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