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Mouse Anti-PLD1 Recombinant Antibody (2F3) (CBMAB-A6786-LY)

The product is antibody recognizes PLD1. The antibody 2F3 immunoassay techniques such as: WB, ELISA.
See all PLD1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2F3
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
PLD1 (NP_002653, 965 a.a. ~ 1074 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
phospholipase D1, phosphatidylcholine-specific
Introduction
Phosphatidylcholine (PC)-specific phospholipases D (PLDs; EC 3.1.4.4) catalyze the hydrolysis of PC to produce phosphatidic acid and choline. A range of agonists acting through G protein-coupled receptors and receptor tyrosine kinases stimulate this hydrolysis. PC-specific PLD activity has been implicated in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis (Hammond et al., 1995 [PubMed 8530346]).[supplied by OMIM
Entrez Gene ID
5337
UniProt ID
Q13393
Function
Function as phospholipase selective for phosphatidylcholine (PubMed:8530346, PubMed:9582313).
Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).
Biological Process
ChemotaxisManual Assertion Based On ExperimentTAS:ProtInc
Inositol lipid-mediated signalingIEA:InterPro
Phosphatidic acid biosynthetic processTAS:Reactome
Phospholipid catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of translationManual Assertion Based On ExperimentIMP:CACAO
Ras protein signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Regulation of microvillus assemblyManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of synaptic vesicle cycleManual Assertion Based On ExperimentIDA:SynGO
Regulation of vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Small GTPase mediated signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm, perinuclear region
Endoplasmic reticulum membrane
Golgi apparatus membrane
Late endosome membrane
Involvement in disease
Cardiac valvular defect, developmental (CVDD):
An autosomal recessive form of congenital heart defects, characterized by valvular malformations involving the pulmonic, tricuspid and mitral valves.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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