PLXNA3

PLXNA3 is a member of the plexin class of proteins. The encoded protein is a class 3 semaphorin receptor, and may be involved in cytoskeletal remodeling and as well as apoptosis. Studies of a similar gene in zebrafish suggest that it is important for axon pathfinding in the developing nervous system.

Full Name

Plexin A3

Function

Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.

Biological Process

Axon extension involved in axon guidanceIEA:Ensembl
Axon guidanceISS:UniProtKB
Branchiomotor neuron axon guidanceISS:UniProtKB
Facial nerve structural organizationISS:UniProtKB
Gonadotrophin-releasing hormone neuronal migration to the hypothalamusIEA:Ensembl
Hippocampus developmentISS:UniProtKB
Negative chemotaxisIEA:Ensembl
Negative regulation of axon extension involved in axon guidanceIEA:Ensembl
Negative regulation of cell adhesionManual Assertion Based On ExperimentIBA:GO_Central
Neuron projection guidanceISS:UniProtKB
Olfactory nerve formationIEA:Ensembl
Positive regulation of axonogenesisManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cytoskeleton organizationISS:UniProtKB
Pyramidal neuron developmentISS:UniProtKB
Regulation of cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Regulation of GTPase activityManual Assertion Based On ExperimentIBA:GO_Central
Semaphorin-plexin signaling pathway1 PublicationNAS:BHF-UCL
Semaphorin-plexin signaling pathway involved in axon guidanceISS:UniProtKB
Trigeminal nerve structural organizationISS:UniProtKB

Cellular Location

Cell membrane

Topology

Extracellular: 20-1220
Helical: 1221-1241
Cytoplasmic: 1242-1871