PMFBP1

PMFBP1 (Polyamine Modulated Factor 1 Binding Protein 1) is a protein coding gene, which may play a role in sperm morphology especially the sperm tail and consequently affect fertility. May also be involved in the general organization of cellular cytoskeleton.

Full Name

polyamine modulated factor 1 binding protein 1

Function

Required for normal spermatogenesis (PubMed:1770140, PubMed:30032984, PubMed:30298696).
It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity (PubMed:30032984).
May also be involved in the general organization of cellular cytoskeleton (By similarity).

Biological Process

SpermatogenesisManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cell projection, cilium, flagellum
Localized at the sperm head-tail connecting piece (PubMed:30032984, PubMed:30298696).
During spermatogenesis, it is first observed in the cytoplasm of round spermatids, it later appears in the implantation fossa region of the sperm nucleus during sperm head elongation and differentiation, and finally it localizes to the head-tail connecting piece (By similarity).

Involvement in disease

Spermatogenic failure 31 (SPGF31):
An autosomal recessive infertility disorder caused by spermatogenesis defects that result in oligozoospermia with a high proportion of acephalic sperm.

Anti-PMFBP1 antibodies

Mouse Anti-PMFBP1 Recombinant Antibody (4G9) (CBMAB-P2222-YC)

Datasheet

SDS

Target: PMFBP1

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 4G9

Application*: E, P, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)