Mouse Anti-PMFBP1 Recombinant Antibody (4G9) (CBMAB-P2222-YC)

Name: Mouse Anti-PMFBP1 Recombinant Antibody (4G9)
SKU: CBMAB-P2222-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

4G9

Application

ELISA, IHC-P, WB

Immunogen

PMFBP1 (NP_112583, 99-197 aa) partial recombinant protein with GST tag. Immunogen sequence: FHTEELQTSY YSLRQYQSIL EKQTSDLVLL HHHCKLKEDE VILYEEEMGN HNENTGEKLH LAQEQLALAG DKIASLERSL NLYRDKYQSS LSNIELLEC

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Epitope

aa 99-197

More Infomation

Target

Full Name

polyamine modulated factor 1 binding protein 1

Introduction

PMFBP1 (Polyamine Modulated Factor 1 Binding Protein 1) is a protein coding gene, which may play a role in sperm morphology especially the sperm tail and consequently affect fertility. May also be involved in the general organization of cellular cytoskeleton.

Entrez Gene ID

83449

UniProt ID

Q8TBY8

Alternative Names

PMF-1-Binding Protein; Polyamine-Modulated Factor 1-Binding Protein 1

Function

Required for normal spermatogenesis (PubMed:1770140, PubMed:30032984, PubMed:30298696).
It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity (PubMed:30032984).
May also be involved in the general organization of cellular cytoskeleton (By similarity).

Biological Process

SpermatogenesisManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cell projection, cilium, flagellum
Localized at the sperm head-tail connecting piece (PubMed:30032984, PubMed:30298696).
During spermatogenesis, it is first observed in the cytoplasm of round spermatids, it later appears in the implantation fossa region of the sperm nucleus during sperm head elongation and differentiation, and finally it localizes to the head-tail connecting piece (By similarity).

Involvement in disease

Spermatogenic failure 31 (SPGF31):
An autosomal recessive infertility disorder caused by spermatogenesis defects that result in oligozoospermia with a high proportion of acephalic sperm.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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