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Mouse Anti-PMFBP1 Recombinant Antibody (4G9) (CBMAB-P2222-YC)

Provided herein is a Mouse monoclonal antibody against Human Polyamine Modulated Factor 1 Binding Protein 1. The antibody can be used for immunoassay techniques, such as ELISA, IHC-P, WB.
See all PMFBP1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4G9
Antibody Isotype
IgG2b, κ
Application
ELISA, IHC-P, WB

Basic Information

Immunogen
PMFBP1 (NP_112583, 99-197 aa) partial recombinant protein with GST tag. Immunogen sequence: FHTEELQTSY YSLRQYQSIL EKQTSDLVLL HHHCKLKEDE VILYEEEMGN HNENTGEKLH LAQEQLALAG DKIASLERSL NLYRDKYQSS LSNIELLEC
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 99-197

Target

Full Name
polyamine modulated factor 1 binding protein 1
Introduction
PMFBP1 (Polyamine Modulated Factor 1 Binding Protein 1) is a protein coding gene, which may play a role in sperm morphology especially the sperm tail and consequently affect fertility. May also be involved in the general organization of cellular cytoskeleton.
Entrez Gene ID
UniProt ID
Alternative Names
PMF-1-Binding Protein; Polyamine-Modulated Factor 1-Binding Protein 1
Function
Required for normal spermatogenesis (PubMed:1770140, PubMed:30032984, PubMed:30298696).
It functions as a scaffold protein that attaches the sperm head-tail connecting piece to the nuclear envelope, thus maintaining sperm head and tail integrity (PubMed:30032984).
May also be involved in the general organization of cellular cytoskeleton (By similarity).
Biological Process
SpermatogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell projection, cilium, flagellum
Localized at the sperm head-tail connecting piece (PubMed:30032984, PubMed:30298696).
During spermatogenesis, it is first observed in the cytoplasm of round spermatids, it later appears in the implantation fossa region of the sperm nucleus during sperm head elongation and differentiation, and finally it localizes to the head-tail connecting piece (By similarity).
Involvement in disease
Spermatogenic failure 31 (SPGF31):
An autosomal recessive infertility disorder caused by spermatogenesis defects that result in oligozoospermia with a high proportion of acephalic sperm.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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