PNLIP
PNLIP is a member of the lipase family of proteins. The encoded enzyme is secreted by the pancreas and hydrolyzes triglycerides in the small intestine, and is essential for the efficient digestion of dietary fats. Inhibition of the encoded enzyme may prevent high-fat diet-induced obesity in mice and result in weight loss in human patients with obesity. Mutations in this gene cause congenital pancreatic lipase deficiency, a rare disorder characterized by steatorrhea.
Full Name
Pancreatic Lipase
Function
Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones.
Biological Process
Intestinal cholesterol absorptionIEA:Ensembl
Lipid catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Lipid metabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of triglyceride lipase activityManual Assertion Based On ExperimentIDA:CACAO
Lipid catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Lipid metabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of triglyceride lipase activityManual Assertion Based On ExperimentIDA:CACAO
Cellular Location
Secreted
Involvement in disease
Pancreatic lipase deficiency (PNLIPD):
An autosomal recessive disorder characterized by exocrine pancreatic failure. Clinical findings include oily/greasy stools from infancy or early childhood, absence of discernible pancreatic disease, and significantly decreased pancreatic lipolytic activity.
An autosomal recessive disorder characterized by exocrine pancreatic failure. Clinical findings include oily/greasy stools from infancy or early childhood, absence of discernible pancreatic disease, and significantly decreased pancreatic lipolytic activity.
View more
Anti-PNLIP antibodies
+ Filters
Loading...
CompareTarget: PNLIP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4I2
Application*: E
Target: PNLIP
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: LIP10-143.3
Application*: E
Target: PNLIP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: LIP10-106.4
Application*: E
Target: PNLIP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2316
Application*: E
Target: PNLIP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2315
Application*: E
Target: PNLIP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-2314
Application*: E
Target: PNLIP
Sensitivity: 0.143 mU/mL
Detection Range: 0.3-90 mU/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Pig
Assay Type: Sandwich
Reactivity: Pig
Target: PNLIP
Sensitivity: 0.08 ng/mL
Detection Range: 0.2-60 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rabbit
Assay Type: Sandwich
Reactivity: Rabbit
Target: Pnlip
Sensitivity: 0.14 ng/mL
Detection Range: 0.3-90 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Target: Pnlip
Sensitivity: 0.25 ng/mL
Detection Range: 0.5-100 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Rat
Assay Type: Sandwich
Reactivity: Rat
Target: PNLIP
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-465
Tag: His Tag
More Infomation
Hot products 
-
Rat Anti-ABCC11 Recombinant Antibody (V2-179001) (CBMAB-A0236-YC)
-
Mouse Anti-FLI1 Recombinant Antibody (CBXF-0733) (CBMAB-F0435-CQ)
-
Mouse Anti-AMOT Recombinant Antibody (CBYC-A564) (CBMAB-A2552-YC)
-
Mouse Anti-ADAM29 Recombinant Antibody (V2-179787) (CBMAB-A1149-YC)
-
Rabbit Anti-DLK1 Recombinant Antibody (9D8) (CBMAB-D1061-YC)
-
Mouse Anti-Gram Positive Bacteria LTA Recombinant Antibody (CBMC-C0664) (CBMAB-V208-1410-CQ)
-
Mouse Anti-CD24 Recombinant Antibody (ALB9) (CBMAB-0176CQ)
-
Mouse Anti-GPRC5C Recombinant Antibody (CBFYH-0464) (CBMAB-H0521-FY)
-
Rabbit Anti-ATF4 Recombinant Antibody (D4B8) (CBMAB-A3872-YC)
-
Mouse Anti-CCNH Recombinant Antibody (CBFYC-1054) (CBMAB-C1111-FY)
-
Mouse Anti-EGR1 Recombinant Antibody (CBWJZ-100) (CBMAB-Z0289-WJ)
-
Mouse Anti-AFDN Recombinant Antibody (V2-58751) (CBMAB-L0408-YJ)
-
Mouse Anti-AAV-5 Recombinant Antibody (V2-503417) (CBMAB-V208-1369-FY)
-
Mouse Anti-CD33 Recombinant Antibody (P67.6) (CBMAB-C10189-LY)
-
Rat Anti-(1-5)-α-L-Arabinan Recombinant Antibody (V2-501861) (CBMAB-XB0003-YC)
-
Mouse Anti-ACTB Recombinant Antibody (V2-179553) (CBMAB-A0870-YC)
-
Mouse Anti-C5AR1 Recombinant Antibody (R63) (CBMAB-C9553-LY)
-
Mouse Anti-BBS2 Recombinant Antibody (CBYY-0253) (CBMAB-0254-YY)
-
Mouse Anti-AP4E1 Recombinant Antibody (32) (CBMAB-A2996-YC)
-
Mouse Anti-B2M Recombinant Antibody (CBYY-0050) (CBMAB-0050-YY)
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
Online Inquiry