PNLIP

PNLIP is a member of the lipase family of proteins. The encoded enzyme is secreted by the pancreas and hydrolyzes triglycerides in the small intestine, and is essential for the efficient digestion of dietary fats. Inhibition of the encoded enzyme may prevent high-fat diet-induced obesity in mice and result in weight loss in human patients with obesity. Mutations in this gene cause congenital pancreatic lipase deficiency, a rare disorder characterized by steatorrhea.

Pancreatic Lipase

Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones.

Intestinal cholesterol absorptionIEA:Ensembl
Lipid catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Lipid metabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of triglyceride lipase activityManual Assertion Based On ExperimentIDA:CACAO

Secreted

Pancreatic lipase deficiency (PNLIPD):
An autosomal recessive disorder characterized by exocrine pancreatic failure. Clinical findings include oily/greasy stools from infancy or early childhood, absence of discernible pancreatic disease, and significantly decreased pancreatic lipolytic activity.