PNLIP

PNLIP is a member of the lipase family of proteins. The encoded enzyme is secreted by the pancreas and hydrolyzes triglycerides in the small intestine, and is essential for the efficient digestion of dietary fats. Inhibition of the encoded enzyme may prevent high-fat diet-induced obesity in mice and result in weight loss in human patients with obesity. Mutations in this gene cause congenital pancreatic lipase deficiency, a rare disorder characterized by steatorrhea.
Full Name
Pancreatic Lipase
Function
Plays an important role in fat metabolism. It preferentially splits the esters of long-chain fatty acids at positions 1 and 3, producing mainly 2-monoacylglycerol and free fatty acids, and shows considerably higher activity against insoluble emulsified substrates than against soluble ones.
Biological Process
Intestinal cholesterol absorptionIEA:Ensembl
Lipid catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Lipid metabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of triglyceride lipase activityManual Assertion Based On ExperimentIDA:CACAO
Cellular Location
Secreted
Involvement in disease
Pancreatic lipase deficiency (PNLIPD):
An autosomal recessive disorder characterized by exocrine pancreatic failure. Clinical findings include oily/greasy stools from infancy or early childhood, absence of discernible pancreatic disease, and significantly decreased pancreatic lipolytic activity.
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Anti-PNLIP antibodies

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Mouse Anti-PNLIP Recombinant Antibody (4I2) (CBMAB-P2253-YC)

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Target: PNLIP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4I2
Application*: E
Datasheet SDS

Mouse Anti-PNLIP Recombinant Antibody (LIP10-143.3) (CBMAB-L2613-YJ)

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Target: PNLIP
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: LIP10-143.3
Application*: E
Datasheet SDS

Mouse Anti-PNLIP Recombinant Antibody (LIP10-106.4) (CBMAB-L2612-YJ)

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Target: PNLIP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: LIP10-106.4
Application*: E
Datasheet SDS

Mouse Anti-PNLIP Recombinant Antibody (CBYJL-2316) (CBMAB-L2611-YJ)

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Target: PNLIP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2316
Application*: E
Datasheet SDS

Mouse Anti-PNLIP Recombinant Antibody (CBYJL-2315) (CBMAB-L2610-YJ)

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Target: PNLIP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJL-2315
Application*: E
Datasheet SDS

Mouse Anti-PNLIP Recombinant Antibody (CBYJL-2314) (CBMAB-L2609-YJ)

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Target: PNLIP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-2314
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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