PODXL2

PODXL2 is a member of the CD34 family of cell surface transmembrane proteins, which are characterized by an N-terminal extracellular mucin domain, globular and stalk domains, a single pass transmembrane region, and a charged cytoplasmic tail. The encoded protein is a ligand for vascular selectins.
Full Name
Podocalyxin Like 2
Function
Acts as a ligand for vascular selectins. Mediates rapid rolling of leukocytes over vascular surfaces through high affinity divalent cation-dependent interactions with E-, P- and L-selectins.
Biological Process
Leukocyte tethering or rollingManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Membrane
Topology
Extracellular: 33-500
Helical: 501-521
Cytoplasmic: 522-605
PTM
Glycosylated; contains chondroitin sulfate. Displays sialylated O-linked oligosaccharides.
Sulfation is necessary for interaction with SELL. Sialylated O-linked oligosaccharides are necessary for interaction with SELL, SELE and SELP.
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Anti-PODXL2 antibodies

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Target: PODXL2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYC-P488
Application*: F, IC, IF
Target: PODXL2
Host: Rat
Antibody Isotype: IgM
Specificity: Human, Mouse
Clone: CBFYE-1600
Application*: F, IP
Target: PODXL2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYE-1599
Application*: F, IH, IP
Target: PODXL2
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBFYE-1597
Application*: WB
Target: PODXL2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYE-0081
Application*: F, IC, MC
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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