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PPIH

PPIH is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP.

Full Name

Peptidylprolyl Isomerase H

Function

PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357).
Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone.

Biological Process

mRNA splicing, via spliceosome1 PublicationIC:BHF-UCL
Positive regulation of viral genome replicationManual Assertion Based On ExperimentIMP:UniProtKB
Protein foldingManual Assertion Based On ExperimentIBA:GO_Central
Protein peptidyl-prolyl isomerizationManual Assertion Based On ExperimentIDA:UniProtKB
Protein-containing complex assemblyManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Nucleus speckle
Cytoplasm
Colocalizes with spliceosomal snRNPs. A small proportion may also be cytoplasmic.

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Anti-PPIH antibodies

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Mouse Anti-PPIH Recombinant Antibody (C-5) (CBMAB-P2534-YC)

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Target: PPIH

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: C-5

Application*: WB, IP, IF, P, E

Mouse Anti-PPIH Recombinant Antibody (2D11) (CBMAB-P2533-YC)

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Target: PPIH

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 2D11

Application*: WB

Mouse Anti-PPIH Recombinant Antibody (1C6) (CBMAB-P2532-YC)

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Target: PPIH

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1C6

Application*: WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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