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Mouse Anti-PPIH Recombinant Antibody (1C6) (CBMAB-P2532-YC)

Provided herein is a Mouse monoclonal antibody against Human Peptidylprolyl Isomerase H. The antibody can be used for immunoassay techniques, such as WB.
See all PPIH antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1C6
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human PPIH (NP_006338) produced in E. coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
PBS, pH 7.3, 1% BSA, 50% glycerol, 0.02% sodium azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Peptidylprolyl Isomerase H
Introduction
PPIH is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP.
Entrez Gene ID
10465
UniProt ID
O43447
Alternative Names
CYP-20; CYPH; SnuCyp-20; USA-CYP
Function
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357).
Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone.
Biological Process
mRNA splicing, via spliceosome1 PublicationIC:BHF-UCL
Positive regulation of viral genome replicationManual Assertion Based On ExperimentIMP:UniProtKB
Protein foldingManual Assertion Based On ExperimentIBA:GO_Central
Protein peptidyl-prolyl isomerizationManual Assertion Based On ExperimentIDA:UniProtKB
Protein-containing complex assemblyManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus speckle
Cytoplasm
Colocalizes with spliceosomal snRNPs. A small proportion may also be cytoplasmic.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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