PRAP1

Full Name

proline-rich acidic protein 1

Function

Lipid-binding protein which promotes lipid absorption by facilitating MTTP-mediated lipid transfer (mainly triglycerides and phospholipids) and MTTP-mediated apoB lipoprotein assembly and secretion (By similarity).
Protects the gastrointestinal epithelium from irradiation-induced apoptosis (By similarity).
May play an important role in maintaining normal growth homeostasis in epithelial cells (PubMed:14583459).
Involved in p53/TP53-dependent cell survival after DNA damage (PubMed:23235459).
May down-regulate the expression of MAD1L1 and exert a suppressive role in mitotic spindle assembly checkpoint in hepatocellular carcinomas (PubMed:24374861).

Biological Process

Cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to X-rayISS:UniProtKB
Deactivation of mitotic spindle assembly checkpointManual Assertion Based On ExperimentIDA:UniProtKB
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of intestinal lipid absorptionISS:UniProtKB
Positive regulation of phospholipid transportISS:UniProtKB
Positive regulation of triglyceride transportISS:UniProtKB

Cellular Location

Secreted
Endoplasmic reticulum