Mouse Anti-PRAP1 Recombinant Antibody (2B4) (CBMAB-A6993-LY)

Name: Mouse Anti-PRAP1 Recombinant Antibody (2B4)
SKU: CBMAB-A6993-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

2B4

Application

WB, ELISA

Immunogen

PRAP1 (NP_660203.2, 1 a.a. ~ 151 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

proline-rich acidic protein 1

Entrez Gene ID

118471

UniProt ID

Q96NZ9

Alternative Names

MGC126792; PRO1195; RP11-122K13.6; UPA

Function

Lipid-binding protein which promotes lipid absorption by facilitating MTTP-mediated lipid transfer (mainly triglycerides and phospholipids) and MTTP-mediated apoB lipoprotein assembly and secretion (By similarity).
Protects the gastrointestinal epithelium from irradiation-induced apoptosis (By similarity).
May play an important role in maintaining normal growth homeostasis in epithelial cells (PubMed:14583459).
Involved in p53/TP53-dependent cell survival after DNA damage (PubMed:23235459).
May down-regulate the expression of MAD1L1 and exert a suppressive role in mitotic spindle assembly checkpoint in hepatocellular carcinomas (PubMed:24374861).

Biological Process

Cellular response to DNA damage stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Cellular response to X-rayISS:UniProtKB
Deactivation of mitotic spindle assembly checkpointManual Assertion Based On ExperimentIDA:UniProtKB
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of intestinal lipid absorptionISS:UniProtKB
Positive regulation of phospholipid transportISS:UniProtKB
Positive regulation of triglyceride transportISS:UniProtKB

Cellular Location

Secreted
Endoplasmic reticulum

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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