PRELID1

PRELID1 is a member of the late embryogenesis abundant motif-containing protein family. The encoded protein is localized to mitochondria and may function as a cytoprotectant by regulating cell death and differentiation.

Full Name

PRELI domain containing 1

Function

Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane. Regulates the mitochondrial apoptotic pathway in primary Th cells. Regulates Th cell differentiation by down-regulating STAT6 thereby reducing IL-4-induced Th2 cell number. May be important for the development of vital and immunocompetent organs.

Biological Process

Apoptotic processIEA:UniProtKB-KW
Intermembrane lipid transferIEA:GOC
Negative regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of mitochondrial membrane potentialManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of release of cytochrome c from mitochondriaManual Assertion Based On ExperimentIDA:UniProtKB
Phospholipid transportManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of cellular respirationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of endopeptidase activityManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of phospholipid transportManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of T cell apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of membrane lipid distributionManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of mitochondrial membrane potentialManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of T cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Mitochondrion
Mitochondrion intermembrane space